Abstract:
Heterocycles have contributed to the development of society from a
biological and industrial point of view as well as to improve the quality
of life. During the past few decades, interest has been rapidly growing
in gaining insight into the properties and transformation of these
heterocycles. As a result, variety of new compounds is being added to
this field every year. Among the sulfur and nitrogen containing
heterocyclic compounds, thiosemicarbazides and thiosemicarbazones
have potential pharmacological activities. The hydrazides addition to
various isothiocyanates is one of the convenient methods of the
synthesis of substituted thiosemicarbazides, which are of great interest
not only in terms of a possible study of biological activity, but also as
the starting compounds for the synthesis. Thiosemicarbazides is a
unique class of organic compounds which is not known only for its
various biological activities but also as metal-chelating and
anticorrosion agents. This review is focused on the current rapid proliferation of a huge
amount of biological data which led to a set of bioinformatics application and their use in the
process of drug discovery. It also provides an insight of the significance of computational
studies, becoming important for the support of activities reported.
