Please use this identifier to cite or link to this item: https://dr.ddn.upes.ac.in//xmlui/handle/123456789/1903
Title: Anticancer Activities of Thiosemicarbazides/Thiosemicarbazones: A Review
Authors: Arora, Shefali
Agarwal, Shilpi
Singhal, Shailey
Keywords: Medical Science
Issue Date: 2014
Citation: International Journal of Pharmacy and Pharmaceutical Sciences, Vol 6, Issue 9, 2014
Abstract: There have been tremendous development in the chemotherapy of cancer and researches are still developing new and more effective drugs to combat this disease. Thiosemicarbazides and thiosemicarbazone possess a wide range of biological applications. This key biological role is often related with their capability to inhibit the enzyme ribonucleotide reductase, similar to what is observed with potent anticancer drugs such as triapine and methisazone. Recent studies have revealed that thiosemicarbazones can inhibit topoisomerase II enzyme. This review discusses current advances of an emerging ‘new wave’ of thiosemicarbazide/thiosemicarbazone and their metal complexes as potent anticancer agents, mode of action and toxicity caused by them.
URI: http://hdl.handle.net/123456789/1903
ISSN: 0975-1491
Appears in Collections:Published papers

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